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Journal: International Journal of Molecular Sciences
Article Title: Claudin-1 Contributes to Gastrointestinal Stromal Tumors (GIST) Resistance to Imatinib Mesylate (IM) via Regulation of FGFR-Signaling
doi: 10.3390/ijms26178138
Figure Lengend Snippet: Inhibition of CLDN1 with PDS-0330 in GIST T-1R and GIST 430 cells. GIST T-1R ( A ) and GIST 430 ( B ) cells were treated with PDS-0330 (5 µM) or imatinib (IM) (1 µM) alone or in combination for 72 h and subjected to western blotting analysis to examine the expression of apoptotic markers, such as cleaved forms of PARP and caspase-3, phospho-KIT Y719, and c-KIT. Actin staining was used to show the comparable amounts of protein loaded into each sample.
Article Snippet:
Techniques: Inhibition, Western Blot, Expressing, Staining